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Nevertheless, the exact same concentration of WIN but not other CB1R agonists, improves intracellular Ca2+ focus by way of Gq/eleven protein in transfected HEK-293 cells and cultured hippocampal neurons with endogenous receptor expression [ninety three]. Also, in mice hippocampal slices, CB1R expressed in astrocytes is coupled to Gq/11, will increa